Magnetic resonance approaches to brain aging and Alzheimer disease-associated neuropathology

Valerie C. Anderson, Zachary N. Litvack, Jeffrey A. Kaye

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The noninvasive, nonradioactive, quantitative nature of magnetic resonance techniques has propelled them to the forefront of neuroscience and neuropsychiatric research. In particular, recent advances have confirmed their enormous potential in patients with Alzheimer disease (AD). Structural and functional magnetic resonance (MR) imaging have demonstrated significant correlation with clinical outcomes and underlying pathology and are used increasingly in the AD clinic. This review will highlight the role of high-resolution structural MR imaging and functional magnetic resonance imaging in the identification of atrophic and hemodynamic changes in AD and their potential as diagnostic biomarkers and surrogates of therapeutic response. Advanced MR techniques based on diffusion, perfusion, and neurochemical abnormalities in the aging brain will be presented briefly. These newer techniques continue to expand our understanding of neuropathology in the aging brain and are likely to play an important clinical role in the future.

Original languageEnglish (US)
Pages (from-to)439-452
Number of pages14
JournalTopics in Magnetic Resonance Imaging
Issue number6
StatePublished - Dec 2005


  • Aging
  • Alzheimer disease
  • Dementia
  • Functional
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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