Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification

J. Zheng; Y. Zou; A. L. Nuttall; J. Santos-Sacchi

Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification

J. Zheng, Y. Zou, A. L. Nuttall, J. Santos-Sacchi

Otolaryngology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

There is evidence that intracellular chloride ions modulate prestin function. This study investigated how chloride ions (Cl^-) influence cochlear sensitivity and OHC electromotility. Lowering perilymph Cl^- concentration greatly reduced the magnitude of basal turn BM motion and the electrically evoked otoacoustic emissions. These effects could be modulated by tributyltin (TBT, a Cl^- ionophore). The results indicate that the electrochemical drive for Cl^- is important for normal activity of prestin.

Original language	English (US)
Title of host publication	Auditory Mechanisms
Subtitle of host publication	Processes and Models - Proceedings of the 9th International Symposium
Editors	Alfred L. Nuttall, Tianying Ren, Peter Gillespie, Karl Grosh, Egbert de Boer
Publisher	World Scientific Publishing Co. Pte Ltd
Pages	107-108
Number of pages	2
ISBN (Electronic)	9812568247, 9789812568243
State	Published - 2005
Event	9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 - Portland, United States Duration: Jul 23 2005 → Jul 28 2005

Publication series

Name	Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium

Conference

Conference	9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005
Country/Territory	United States
City	Portland
Period	7/23/05 → 7/28/05

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

Cite this

Zheng, J., Zou, Y., Nuttall, A. L., & Santos-Sacchi, J. (2005). Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification. In A. L. Nuttall, T. Ren, P. Gillespie, K. Grosh, & E. de Boer (Eds.), Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium (pp. 107-108). (Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium). World Scientific Publishing Co. Pte Ltd.

Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification. / Zheng, J.; Zou, Y.; Nuttall, A. L. et al.
Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium. ed. / Alfred L. Nuttall; Tianying Ren; Peter Gillespie; Karl Grosh; Egbert de Boer. World Scientific Publishing Co. Pte Ltd, 2005. p. 107-108 (Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zheng, J, Zou, Y, Nuttall, AL & Santos-Sacchi, J 2005, Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification. in AL Nuttall, T Ren, P Gillespie, K Grosh & E de Boer (eds), Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium. Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium, World Scientific Publishing Co. Pte Ltd, pp. 107-108, 9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005, Portland, United States, 7/23/05.

Zheng J, Zou Y, Nuttall AL, Santos-Sacchi J. Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification. In Nuttall AL, Ren T, Gillespie P, Grosh K, de Boer E, editors, Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium. World Scientific Publishing Co. Pte Ltd. 2005. p. 107-108. (Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium).

Zheng, J. ; Zou, Y. ; Nuttall, A. L. et al. / Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification. Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium. editor / Alfred L. Nuttall ; Tianying Ren ; Peter Gillespie ; Karl Grosh ; Egbert de Boer. World Scientific Publishing Co. Pte Ltd, 2005. pp. 107-108 (Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium).

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title = "Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification",

abstract = "There is evidence that intracellular chloride ions modulate prestin function. This study investigated how chloride ions (Cl-) influence cochlear sensitivity and OHC electromotility. Lowering perilymph Cl- concentration greatly reduced the magnitude of basal turn BM motion and the electrically evoked otoacoustic emissions. These effects could be modulated by tributyltin (TBT, a Cl- ionophore). The results indicate that the electrochemical drive for Cl- is important for normal activity of prestin.",

author = "J. Zheng and Y. Zou and Nuttall, {A. L.} and J. Santos-Sacchi",

note = "Funding Information: Supported by NIH NIDCD DC 00141 (ALN) and DC 00273 (JSS). Publisher Copyright: Copyright {\textcopyright} 2006 by World Scientific Publishing Co. Pte. Ltd.; 9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 ; Conference date: 23-07-2005 Through 28-07-2005",

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AB - There is evidence that intracellular chloride ions modulate prestin function. This study investigated how chloride ions (Cl-) influence cochlear sensitivity and OHC electromotility. Lowering perilymph Cl- concentration greatly reduced the magnitude of basal turn BM motion and the electrically evoked otoacoustic emissions. These effects could be modulated by tributyltin (TBT, a Cl- ionophore). The results indicate that the electrochemical drive for Cl- is important for normal activity of prestin.

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Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification

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