TY - JOUR
T1 - Massive verapamil ingestion
T2 - A report of two cases and a review of the literature
AU - Horowitz, B. Zane
AU - Rhee, Kenneth J.
PY - 1989/11
Y1 - 1989/11
N2 - This report describes two patients who were victims of massive verapamil ingestion and then reviews the available literature. Because verapamil blocks the slow calcium channels of the heart and blood vessels, the use of calcium as a treatment would be logical. In the two cases reported here, calcium was only transiently effective in maintaining cardiac output and blood pressure. Several other agents were then used and most were ineffective. This is similar to experience reported in the literature that suggests that no single agent is capable of reversing verapamil's negative inotropic, dromotropic, chronotropic, and vascular smooth muscle effects.
AB - This report describes two patients who were victims of massive verapamil ingestion and then reviews the available literature. Because verapamil blocks the slow calcium channels of the heart and blood vessels, the use of calcium as a treatment would be logical. In the two cases reported here, calcium was only transiently effective in maintaining cardiac output and blood pressure. Several other agents were then used and most were ineffective. This is similar to experience reported in the literature that suggests that no single agent is capable of reversing verapamil's negative inotropic, dromotropic, chronotropic, and vascular smooth muscle effects.
KW - Verapamil
KW - calcium channel blockers
UR - http://www.scopus.com/inward/record.url?scp=0024428779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024428779&partnerID=8YFLogxK
U2 - 10.1016/0735-6757(89)90287-8
DO - 10.1016/0735-6757(89)90287-8
M3 - Article
C2 - 2572226
AN - SCOPUS:0024428779
SN - 0735-6757
VL - 7
SP - 624
EP - 631
JO - American Journal of Emergency Medicine
JF - American Journal of Emergency Medicine
IS - 6
ER -