Mechanisms of Ion Transport Regulation by Microfilaments

Zhihong Hu, Daniel R. Clayburgh, Jerrold R. Turner

Research output: Chapter in Book/Report/Conference proceedingChapter


A major function of transporting epithelia is vectorial ion movement. This is accomplished by ion channels, pumps, antiporters, and symporters. The activity of these transport proteins is regulated by diverse signaling transduction and membrane trafficking events, many of which involve the actin cytoskeleton. This chapter will focus on the role of actin microfilaments and associated proteins in regulation of ion transport. The apical Na+H+ antiporter NHE3 will be examined in detail in this context due to its general biological importance as well as recent advances that have helped to elucidate the mechanisms of regulation of this protein. Appreciation of the mechanisms of NHE3 regulation should serve as a framework with which to understand cytoskeletal regulation of other transport proteins as well.

Original languageEnglish (US)
Title of host publicationAspects of the Cytoskeleton
EditorsEdward Bittar, Seema Khurana
Number of pages21
StatePublished - 2006
Externally publishedYes

Publication series

NameAdvances in Molecular and Cell Biology
ISSN (Print)1569-2558

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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