TY - JOUR
T1 - Mechanotransduction by Hair Cells
T2 - Models, Molecules, and Mechanisms
AU - Gillespie, Peter G.
AU - Müller, Ulrich
PY - 2009/10/2
Y1 - 2009/10/2
N2 - Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells in the inner ear are specialized mechanoreceptor cells that detect sound and head movement. The mechanotransduction machinery of hair cells is extraordinarily sensitive and responds to minute physical displacements on a submillisecond timescale. The recent discovery of several molecular constituents of the mechanotransduction machinery of hair cells provides a new framework for the interpretation of biophysical data and necessitates revision of prevailing models of mechanotransduction.
AB - Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells in the inner ear are specialized mechanoreceptor cells that detect sound and head movement. The mechanotransduction machinery of hair cells is extraordinarily sensitive and responds to minute physical displacements on a submillisecond timescale. The recent discovery of several molecular constituents of the mechanotransduction machinery of hair cells provides a new framework for the interpretation of biophysical data and necessitates revision of prevailing models of mechanotransduction.
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U2 - 10.1016/j.cell.2009.09.010
DO - 10.1016/j.cell.2009.09.010
M3 - Review article
C2 - 19804752
AN - SCOPUS:70349448090
SN - 0092-8674
VL - 139
SP - 33
EP - 44
JO - Cell
JF - Cell
IS - 1
ER -