TY - JOUR
T1 - Melanopsin is required for non-image-forming photic responses in blind mice
AU - Panda, Satchidananda
AU - Provencio, Ignacio
AU - Tu, Daniel C.
AU - Pires, Susana S.
AU - Rollag, Mark D.
AU - Castrucci, Ana Maria
AU - Pletcher, Mathew T.
AU - Sato, Trey K.
AU - Wiltshire, Tim
AU - Andahazy, Mary
AU - Kay, Steve A.
AU - Van Gelder, Russell N.
AU - Hogenesch, John B.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/7/25
Y1 - 2003/7/25
N2 - Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin, a photopigment that confers this photosensitivity. Mice lacking melanopsin still retain nonvisual photoreception, suggesting that rods and cones could operate in this capacity. We observed that mice with both outer-retinal degeneration and a deficiency in melanopsin exhibited complete loss of photoentrainment of the circadian oscillator, pupillary light responses, photic suppression of arylalkylamine-N-acetyltransferase transcript, and acute suppression of locomotor activity by light. This indicates the importance of both nonvisual and classical visual photoreceptor systems for nonvisual photic responses in mammals.
AB - Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin, a photopigment that confers this photosensitivity. Mice lacking melanopsin still retain nonvisual photoreception, suggesting that rods and cones could operate in this capacity. We observed that mice with both outer-retinal degeneration and a deficiency in melanopsin exhibited complete loss of photoentrainment of the circadian oscillator, pupillary light responses, photic suppression of arylalkylamine-N-acetyltransferase transcript, and acute suppression of locomotor activity by light. This indicates the importance of both nonvisual and classical visual photoreceptor systems for nonvisual photic responses in mammals.
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U2 - 10.1126/science.1086179
DO - 10.1126/science.1086179
M3 - Article
C2 - 12829787
AN - SCOPUS:0041843770
SN - 0036-8075
VL - 301
SP - 525
EP - 527
JO - Science
JF - Science
IS - 5632
ER -