Melatonin treatment of winter depression: A pilot study

Alfred J. Lewy, Vance K. Bauer, Neil L. Cutler, Robert L. Sack

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules. Melatonin treatment significantly decreased depression ratings compared to placebo. If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalPsychiatry Research
Issue number1
StatePublished - Jan 16 1998
Externally publishedYes


  • Melatonin
  • Melatonin phase response curve
  • Phase shift hypothesis
  • Seasonal affective disorder
  • Winter depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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