Membrane estrogen receptor regulation of hypothalamic function

Paul E. Micevych, Martin J. Kelly

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
Issue number2
StatePublished - Sep 2012


  • 17β-estradiol
  • Estrogen receptor alpha
  • Estrogen receptor beta
  • GPR30 (GPER1)
  • Gonadotropin-releasing hormone neuron
  • Gαq-coupled membrane estrogen receptor
  • Proopiomelanocortin neuron
  • mGluR1 receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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