TY - JOUR
T1 - Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides
AU - Schultz, Carsten
AU - Rudolf, Marco T.
AU - Gillandt, Hartmut H.
AU - Traynor-Kaplan, Alexis E.
PY - 1999/12/1
Y1 - 1999/12/1
N2 - The extracellular application of membrane-permeant, bioactivatable derivatives of myo-inositol 1,4,5-trisphosphate and phosphatidyl-myo-inositol 3,4,5-trisphosphate to living cells mimicked the intracellular action of these second messengers, such as elevation of intracellular Ca2+-levels in PC12 cells and inhibition of calcium-mediated chloride secretion in T84 cells, respectively. 3,6-Di-O-butyryl-myo-inositol 1,2,4,5-tetrakisphosphate hexakis(acetoxy methyl) ester and 1',2'-dipalmitoyl-6-O-butyryl-phosphatidyl-myo-inositol 3,4,5-trisphosphate heptakis(acetoxymethyl) ester were prepared by total synthesis.
AB - The extracellular application of membrane-permeant, bioactivatable derivatives of myo-inositol 1,4,5-trisphosphate and phosphatidyl-myo-inositol 3,4,5-trisphosphate to living cells mimicked the intracellular action of these second messengers, such as elevation of intracellular Ca2+-levels in PC12 cells and inhibition of calcium-mediated chloride secretion in T84 cells, respectively. 3,6-Di-O-butyryl-myo-inositol 1,2,4,5-tetrakisphosphate hexakis(acetoxy methyl) ester and 1',2'-dipalmitoyl-6-O-butyryl-phosphatidyl-myo-inositol 3,4,5-trisphosphate heptakis(acetoxymethyl) ester were prepared by total synthesis.
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M3 - Article
AN - SCOPUS:0042855363
SN - 0097-6156
VL - 718
SP - 232
EP - 243
JO - ACS Symposium Series
JF - ACS Symposium Series
ER -