Meningococcal disease

On the basis of observational and epidemiologic studies, in the era of Streptococcus pneumoniae and Haemophilus influenzae vaccination, Neisseria meningitidis infections remain a common cause of sepsis and meningitis, particularly in young children and adolescents. (14)(15)(16)(17) On the basis of expert opinion, antibiotic administration should not be delayed if there is clinical concern for meningococcal disease. The initial preferred agent is a third-generation cephalosporin. (19)(80)(85) On the basis of a systematic review and expert opinion, prompt involvement of public health can help mitigate spread of disease through prophylaxis of close contacts. (42)(101) On the basis of observational studies and expert opinion, all adolescents and children in high-risk groups should receive MenACWY vaccine. (42)(93) On the basis of expert opinion, new meningitis B vaccines are recommended for high-risk children age 10 years or older and may be considered for adolescents for short-term immunogenicity. (94)(110)(113).