Abstract
Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.
Original language | English (US) |
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Pages (from-to) | 178 |
Number of pages | 1 |
Journal | Frontiers in Neuroscience |
Volume | 9 |
Issue number | MAY |
DOIs | |
State | Published - 2015 |
Keywords
- Anxiety
- Glucocorticoids
- HPA axis
- Methamphetamine
- Stress
- Substance abuse
ASJC Scopus subject areas
- General Neuroscience