TY - JOUR
T1 - Methyl selenocysteine
T2 - Single-dose pharmacokinetics in men
AU - Marshall, James R.
AU - Ip, Clement
AU - Romano, Karen
AU - Fetterly, Gerald
AU - Fakih, Marwan
AU - Jovanovic, Borko
AU - Perloff, Marjorie
AU - Crowell, James
AU - Davis, Warren
AU - French-Christy, Renee
AU - Dew, Alexander
AU - Coomes, Margerie
AU - Bergan, Raymond
PY - 2011/11
Y1 - 2011/11
N2 - The recently published report of the SELECT evaluation of selenium and vitamin E provided strong evidence that selenium 200 μg per day in the form of selenomethionine does not protect selenium-replete men against prostate or any other cancer. This seems to refute the result of the much smaller Nutritional Prevention of Cancer (NPC) trial of selenium. Because SELECT did not test the NPC agent, it is possible that the difference between the two trials stems partly from the use of different agents: selenomethionine in SELECT, and selenized yeast in the NPC trial. One of the organic selenium forms suspected of having strong chemopreventive effects, and which may have been present in the NPC agent, is methyl selenocysteine. This study characterizes the single-dose pharmacokinetics of methyl selenocysteine.
AB - The recently published report of the SELECT evaluation of selenium and vitamin E provided strong evidence that selenium 200 μg per day in the form of selenomethionine does not protect selenium-replete men against prostate or any other cancer. This seems to refute the result of the much smaller Nutritional Prevention of Cancer (NPC) trial of selenium. Because SELECT did not test the NPC agent, it is possible that the difference between the two trials stems partly from the use of different agents: selenomethionine in SELECT, and selenized yeast in the NPC trial. One of the organic selenium forms suspected of having strong chemopreventive effects, and which may have been present in the NPC agent, is methyl selenocysteine. This study characterizes the single-dose pharmacokinetics of methyl selenocysteine.
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U2 - 10.1158/1940-6207.CAPR-10-0259
DO - 10.1158/1940-6207.CAPR-10-0259
M3 - Article
C2 - 21846796
AN - SCOPUS:81555202942
SN - 1940-6207
VL - 4
SP - 1938
EP - 1944
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 11
ER -