Abstract
Recent studies have begun to define the role ofmicro-RNAs in regulating the immune response.Micro-RNA155 (mir-155) has been shown to play a role in germinal center formation, T cell inflammation, and regulatory T cell development. In this study, we evaluated the role of mir-155 in cytotoxic T cell function.We report in this study that mice lacking mir-155 have impaired CD8+ T cell responses to infections with lymphocytic choriomeningitis virus and the intracellular bacteria Listeria monocytogenes.We show by a series of adoptive transfer studies that the impaired CD8+ T cell response to L. monocytogenes is T cell intrinsic. In addition, we observed that CD8+ T cells lacking mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking. These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses.
Original language | English (US) |
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Pages (from-to) | 1210-1216 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 190 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology