Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.
|Original language||English (US)|
|Number of pages||12|
|Journal||Journal of Mammary Gland Biology and Neoplasia|
|State||Published - Mar 2007|
- Breast cancer
ASJC Scopus subject areas
- Cancer Research