Mie and Rayleigh modeling of visible-light scattering in neonatal skin

Iyad S. Saidi, Steven L. Jacques, Frank K. Tittel

Research output: Contribution to journalArticlepeer-review

253 Scopus citations


Reduced-scattering coefficients of neonatal skin were deduced in the 450–750-nm range from integrating-sphere measurements of the total reflection and total transmission of 22 skin samples. The reduced-scattering coefficients increased linearly at each wavelength with gestational maturity. The distribution of diametersd and concentration ρA of the skin-sample collagen fibers were measured in histological sections of nine neonatal skin samples of varying gestational ages. An algorithm that calculates Mie scattering by cylinders was used to model the scattering by the collagen fibers in the skin. The fraction of the reduced-scattering coefficient μs′ that was attributable to Mie scattering by collagen fibers, as deduced from wavelength-dependent analysis, increased with gestational age and approached that found for adult skin. An assignment of 1.017 forn rel, the refractive index of the collagen fibers relative to that of the surrounding medium, allowed the values for Mie scattering by collagen fibers, as predicted by the model for each of the nine neonatal skin samples to match the values for Mie scattering by collagen fibers as expected from the measurements of μs′. The Mie-scattering model predicted an increase in scattering with gestational age on the basis of changes in the collagen-fiber diameters, and this increase was proportional to that measured with the integrating-sphere method.

Original languageEnglish (US)
Pages (from-to)7410-7418
Number of pages9
JournalApplied Optics
Issue number31
StatePublished - Nov 1995
Externally publishedYes


  • Mie
  • Neonatal skin
  • Optical properties
  • Rayleigh
  • Scattering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering


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