Mitochondrial genome inheritance and replacement in the human germline

Don P. Wolf, Tomonari Hayama, Shoukhrat Mitalipov

Research output: Contribution to journalComment/debatepeer-review

26 Scopus citations

Abstract

Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own DNA, known as mtDNA, which is inherited exclusively from the mother. The number of mitochondrial genomes varies depending on the cell's energy needs. The mature oocyte contains the highest number of mitochondria of any cell type, although there is little if any mtDNA replication after fertilization until the embryo implants. This has potential repercussions for mitochondrial replacement therapy (MRT; see description of currently employed methods below) used to prevent the transmission of mtDNA-based disorders. If only a few mitochondria with defective mtDNA are left in the embryo and undergo extensive replication, it might therefore thwart the purpose of MRT. In order to improve the safety and efficacy of this experimental therapy, we need a better understanding of how and which mtDNA is tagged for replication versus transcription after fertilization of the oocyte.

Original languageEnglish (US)
Pages (from-to)2177-2181
Number of pages5
JournalEMBO Journal
Volume36
Issue number15
DOIs
StatePublished - Aug 1 2017

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

Fingerprint

Dive into the research topics of 'Mitochondrial genome inheritance and replacement in the human germline'. Together they form a unique fingerprint.

Cite this