Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases

Albin John, Aaron Kubosumi, P. Hemachandra Reddy

    Research output: Contribution to journalReview articlepeer-review

    38 Scopus citations


    MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.

    Original languageEnglish (US)
    Article number340
    Issue number6
    StatePublished - May 28 2020


    • Alzheimer’s disease
    • Huntington’s disease
    • Parkinson’s disease
    • aging
    • microRNAs
    • mitochondrial function and mitophagy
    • mitochondrial microRNAs
    • oxidative stress

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)


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