Abstract
MK-801 is a central nervous system glutamate antagonist that has recently been reported to ameliorate neuronal damage in an animal model of focal cerebral ischaemia. When administered to awake rabbits and cats, MK-801 causes profound and long-lasting sedation. This suggests that MK-801 may have anaesthetic properties. In order to examine this possibility, we determined the effects of a bolus dose of MK-801 on halothane and isoflurane MAC, the electroencephalogram (EEG) and cardiovascular variables in rabbits.
Original language | English (US) |
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Pages (from-to) | S96-S97 |
Journal | Canadian Journal of Anaesthesia |
Volume | 35 |
Issue number | 3 II |
State | Published - 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine