MMP9 potentiates pulmonary metastasis formation

Léon C.L. Van Kempen, Lisa M. Coussens

Research output: Contribution to journalReview articlepeer-review

145 Scopus citations


Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

Original languageEnglish (US)
Pages (from-to)251-252
Number of pages2
JournalCancer Cell
Issue number4
StatePublished - Oct 2002
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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