Abstract
When HL-60 cells are induced to differentiate by dimethyl sulfoxide along a granulocytic pathway there is a fivefold decrease in the total number of transferrin receptors within 3 days, as compared to untreated cells. This decrease is due primarily to a rapid decline in the synthesis of the receptor rather than an increase in the degradation of the receptor. The decrease in transferrin receptor synthesis is a specific and early event that precedes the cessation of cell proliferation, differentiation, and the decrease in total protein synthesis.
Original language | English (US) |
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Pages (from-to) | 89-97 |
Number of pages | 9 |
Journal | Experimental Cell Research |
Volume | 174 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology