Molecular basis of mechanosensory transduction

P. G. Gillespie; R. G. Walker

doi:10.1038/35093011

Molecular basis of mechanosensory transduction

P. G. Gillespie, R. G. Walker

Otolaryngology

Research output: Contribution to journal › Review article › peer-review

561 Scopus citations

Abstract

Mechanotransduction - a cell's conversion of a mechanical stimulus into an electrical signal - reveals vital features of an organism's environment. From hair cells and skin mechanoreceptors in vertebrates, to bristle receptors in flies and touch receptors in worms, mechanically sensitive cells are essential in the life of an organism. The scarcity of these cells and the uniqueness of their transduction mechanisms have conspired to slow molecular characterization of the ensembles that carry out mechanotransduction. But recent progress in both invertebrates and vertebrates is beginning to reveal the identities of proteins essential for transduction.

Original language	English (US)
Pages (from-to)	194-202
Number of pages	9
Journal	Nature
Volume	413
Issue number	6852
DOIs	https://doi.org/10.1038/35093011
State	Published - Sep 13 2001

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AB - Mechanotransduction - a cell's conversion of a mechanical stimulus into an electrical signal - reveals vital features of an organism's environment. From hair cells and skin mechanoreceptors in vertebrates, to bristle receptors in flies and touch receptors in worms, mechanically sensitive cells are essential in the life of an organism. The scarcity of these cells and the uniqueness of their transduction mechanisms have conspired to slow molecular characterization of the ensembles that carry out mechanotransduction. But recent progress in both invertebrates and vertebrates is beginning to reveal the identities of proteins essential for transduction.

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Molecular basis of mechanosensory transduction

Abstract

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