TY - JOUR
T1 - Molecular composition of vestibular hair bundles
AU - Krey, Jocelyn F.
AU - Barr-Gillespie, Peter G.
N1 - Funding Information:
We thank Rachel Dumont for the scanning electron micrograph of Figure 1A. P.G.B.-G. is supported by National Institutes of Health (NIH) Grants R01 DC002368, R01 DC011034, and P30 DC005983; J.F.K. is supported by NIH Grant R03 DC014544.
Publisher Copyright:
© 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - The vertebrate hair bundle, responsible for transduction of mechanical signals into receptor potentials in sensory hair cells, is an evolutionary masterpiece. Composed of actin-filled stereocilia of precisely regulated length, width, and number, the structure of the hair bundle is optimized for sensing auditory and vestibular stimuli. Recent developments in identifying the lipids and proteins constituting the hair bundle, obtained through genetics, biochemistry, and imaging, now permit a description of the consensus composition of vestibular bundles of mouse, rat, and chick.
AB - The vertebrate hair bundle, responsible for transduction of mechanical signals into receptor potentials in sensory hair cells, is an evolutionary masterpiece. Composed of actin-filled stereocilia of precisely regulated length, width, and number, the structure of the hair bundle is optimized for sensing auditory and vestibular stimuli. Recent developments in identifying the lipids and proteins constituting the hair bundle, obtained through genetics, biochemistry, and imaging, now permit a description of the consensus composition of vestibular bundles of mouse, rat, and chick.
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U2 - 10.1101/cshperspect.a033209
DO - 10.1101/cshperspect.a033209
M3 - Article
C2 - 29844221
AN - SCOPUS:85059498575
SN - 2157-1422
VL - 9
JO - Cold Spring Harbor perspectives in medicine
JF - Cold Spring Harbor perspectives in medicine
IS - 1
M1 - a033209
ER -