Molecular diagnosis: Implications for ophthalmology

James T. Rosenbaum, Cailin H. Sibley, Dongseok Choi, Christina A. Harrington, Stephen R. Planck

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalProgress in Retinal and Eye Research
StatePublished - Jan 1 2016


  • Granulomatosis with polyangiitis
  • Molecular diagnosis
  • Nonspecific orbital inflammatory disease
  • Sarcoidosis
  • Thyroid eye disease
  • Transcriptomics

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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