Molecular diagnosis: Implications for ophthalmology

James T. Rosenbaum; Cailin H. Sibley; Dongseok Choi; Christina A. Harrington; Stephen R. Planck

doi:10.1016/j.preteyeres.2015.11.001

Molecular diagnosis: Implications for ophthalmology

James T. Rosenbaum, Cailin H. Sibley, Dongseok Choi, Christina A. Harrington, Stephen R. Planck

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

Original language	English (US)
Pages (from-to)	25-33
Number of pages	9
Journal	Progress in Retinal and Eye Research
Volume	50
DOIs	https://doi.org/10.1016/j.preteyeres.2015.11.001
State	Published - Jan 1 2016

Keywords

Granulomatosis with polyangiitis
Molecular diagnosis
Nonspecific orbital inflammatory disease
Sarcoidosis
Thyroid eye disease
Transcriptomics

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.preteyeres.2015.11.001

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title = "Molecular diagnosis: Implications for ophthalmology",

abstract = "The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as {"}treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations{"} (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.",

keywords = "Granulomatosis with polyangiitis, Molecular diagnosis, Nonspecific orbital inflammatory disease, Sarcoidosis, Thyroid eye disease, Transcriptomics",

author = "Rosenbaum, {James T.} and Sibley, {Cailin H.} and Dongseok Choi and Harrington, {Christina A.} and Planck, {Stephen R.}",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Ltd.",

year = "2016",

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doi = "10.1016/j.preteyeres.2015.11.001",

language = "English (US)",

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T1 - Molecular diagnosis

T2 - Implications for ophthalmology

AU - Rosenbaum, James T.

AU - Sibley, Cailin H.

AU - Choi, Dongseok

AU - Harrington, Christina A.

AU - Planck, Stephen R.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

AB - The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

KW - Granulomatosis with polyangiitis

KW - Molecular diagnosis

KW - Nonspecific orbital inflammatory disease

KW - Sarcoidosis

KW - Thyroid eye disease

KW - Transcriptomics

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DO - 10.1016/j.preteyeres.2015.11.001

M3 - Review article

C2 - 26608807

AN - SCOPUS:84955265030

SN - 1350-9462

VL - 50

SP - 25

EP - 33

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

ER -

Molecular diagnosis: Implications for ophthalmology

Abstract

Keywords

ASJC Scopus subject areas

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