Monoclonal Antibody Therapy of Breastfeeding Patient Infected with SARS-CoV-2: A Case Report

Nicole E. Marshall; Madison B. Blanton; Brianna M. Doratt; Delphine C. Malherbe; Monica Rincon; Ilhem Messaoudi

doi:10.1089/bfm.2023.0102

Monoclonal Antibody Therapy of Breastfeeding Patient Infected with SARS-CoV-2: A Case Report

Nicole E. Marshall, Madison B. Blanton, Brianna M. Doratt, Delphine C. Malherbe, Monica Rincon, Ilhem Messaoudi

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Although safety data demonstrated the efficacy and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination for all individuals over 6 months of age, including pregnant and breastfeeding individuals, optimal treatment courses for symptomatic pregnant and lactating individuals infected with SARS-CoV-2 remain to be defined. Case Description: A coronavirus disease 2019 (COVID-19)-vaccinated breastfeeding woman received anti-SARS-CoV-2 monoclonal antibody treatment casirivimab-imdevimab 5 days after diagnosis of a symptomatic breakthrough SARS-CoV-2 infection. Results and Conclusions: The patient did not present with obvious defects in innate or adaptive cellular subsets, but compared with controls had minimal maternal antibody response to recommended pregnancy vaccinations including SARS-CoV-2 and tetanus, diphtheria, pertussis (TDaP). The outcome of the monoclonal antibody infusion treatment was favorable as it transiently increased SARS-CoV-2 antibody titers in plasma and human milk compartments.

Original language	English (US)
Pages (from-to)	626-630
Number of pages	5
Journal	Breastfeeding Medicine
Volume	18
Issue number	8
DOIs	https://doi.org/10.1089/bfm.2023.0102
State	Published - Aug 1 2023

Keywords

SARS-CoV-2 infection
immune response
lactation
monoclonal antibody therapy

ASJC Scopus subject areas

Pediatrics
Health Policy
Obstetrics and Gynecology
Maternity and Midwifery

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10.1089/bfm.2023.0102

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title = "Monoclonal Antibody Therapy of Breastfeeding Patient Infected with SARS-CoV-2: A Case Report",

abstract = "Introduction: Although safety data demonstrated the efficacy and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination for all individuals over 6 months of age, including pregnant and breastfeeding individuals, optimal treatment courses for symptomatic pregnant and lactating individuals infected with SARS-CoV-2 remain to be defined. Case Description: A coronavirus disease 2019 (COVID-19)-vaccinated breastfeeding woman received anti-SARS-CoV-2 monoclonal antibody treatment casirivimab-imdevimab 5 days after diagnosis of a symptomatic breakthrough SARS-CoV-2 infection. Results and Conclusions: The patient did not present with obvious defects in innate or adaptive cellular subsets, but compared with controls had minimal maternal antibody response to recommended pregnancy vaccinations including SARS-CoV-2 and tetanus, diphtheria, pertussis (TDaP). The outcome of the monoclonal antibody infusion treatment was favorable as it transiently increased SARS-CoV-2 antibody titers in plasma and human milk compartments.",

keywords = "SARS-CoV-2 infection, immune response, lactation, monoclonal antibody therapy",

author = "Marshall, {Nicole E.} and Blanton, {Madison B.} and Doratt, {Brianna M.} and Malherbe, {Delphine C.} and Monica Rincon and Ilhem Messaoudi",

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AU - Blanton, Madison B.

AU - Doratt, Brianna M.

AU - Malherbe, Delphine C.

AU - Rincon, Monica

AU - Messaoudi, Ilhem

PY - 2023/8/1

Y1 - 2023/8/1

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AB - Introduction: Although safety data demonstrated the efficacy and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination for all individuals over 6 months of age, including pregnant and breastfeeding individuals, optimal treatment courses for symptomatic pregnant and lactating individuals infected with SARS-CoV-2 remain to be defined. Case Description: A coronavirus disease 2019 (COVID-19)-vaccinated breastfeeding woman received anti-SARS-CoV-2 monoclonal antibody treatment casirivimab-imdevimab 5 days after diagnosis of a symptomatic breakthrough SARS-CoV-2 infection. Results and Conclusions: The patient did not present with obvious defects in innate or adaptive cellular subsets, but compared with controls had minimal maternal antibody response to recommended pregnancy vaccinations including SARS-CoV-2 and tetanus, diphtheria, pertussis (TDaP). The outcome of the monoclonal antibody infusion treatment was favorable as it transiently increased SARS-CoV-2 antibody titers in plasma and human milk compartments.

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Monoclonal Antibody Therapy of Breastfeeding Patient Infected with SARS-CoV-2: A Case Report

Abstract

Keywords

ASJC Scopus subject areas

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