More clinical lessons from the FIELD study

Sergio Fazio

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Introduction: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study investigated the effect of fenofibrate treatment in 9,795 patients with type 2 diabetes. Results and discussion: Reduction in major coronary events (the primary endpoint) and total cardiovascular disease (CVD) events (the secondary endpoint) was similar (relative risk reduction 11%), but only significant for total CVD events (p∈=∈0.035). The benefit of fenofibrate treatment was greater in patients with mixed dyslipidaemia, especially in those with triglycerides >2.3 mmol/L and low plasma levels of high-density lipoprotein cholesterol (relative risk reduction 27%, p∈=∈0.005). There were also microvascular benefits associated with fenofibrate treatment, specifically reduction in the rate of laser therapy for retinopathy (by 30%, p∈<∈0.001), non-traumatic amputation (by 38%, p∈=∈0.011) and progression of albuminuria (p∈<∈0.002). Fenofibrate was generally well tolerated alone or in combination with a statin. Conclusions: Overall, the FIELD study data support the use of fenofibrate for CVD prevention in diabetes, ideally in patients without prior macrovascular or microvascular complications. Fenofibrate may also have a role as a preventive treatment for diabetic retinopathy. Addition of fenofibrate to statin therapy may a logical progression from the FIELD study data, although the efficacy and tolerability of this approach needs to be evaluated in prospective outcome studies.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalCardiovascular Drugs and Therapy
Issue number3
StatePublished - Jun 2009
Externally publishedYes


  • Cardiovascular disease
  • Fenofibrate
  • Retinopathy
  • Type 2 diabetes

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)


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