Abstract
Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively described; however, the immunological landscape of the term decidua remains poorly understood. We therefore profiled human leukocytes from term decidua collected via scheduled cesarean delivery. Relative to the first trimester, our analyses show a shift from NK cells and macrophages to T cells and enhanced immune activation. Although circulating and decidual T cells are phenotypically distinct, they demonstrate significant clonotype sharing. We also report significant diversity within decidual macrophages, the frequency of which positively correlates with pregravid maternal body mass index. Interestingly, the ability of decidual macrophages to respond to bacterial ligands is reduced with pregravid obesity, suggestive of skewing toward immunoregulation as a possible mechanism to safeguard the fetus against excessive maternal inflammation. These findings are a resource for future studies investigating pathological conditions that compromise fetal health and reproductive success.
Original language | English (US) |
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Article number | 112769 |
Journal | Cell Reports |
Volume | 42 |
Issue number | 7 |
DOIs | |
State | Published - Jul 25 2023 |
Keywords
- CP: Immunology
- TCR
- decidua
- human
- macrophages
- maternal-fetal interface
- obesity
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology