Purpose: To present data to support the hypothesis that human retinoblastoma tumors form by a multistep process. Methods: Survey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes. Conclusion: The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.
|Original language||English (US)|
|Number of pages||16|
|Journal||Transactions of the American Ophthalmological Society|
|State||Published - 1996|
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