Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro

Steven W. Johnson; Yan Na Wu

doi:10.1016/j.brainres.2004.06.022

Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro

Steven W. Johnson, Yan Na Wu

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms.

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	Brain research
Volume	1019
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.06.022
State	Published - Sep 3 2004
Externally published	Yes

Keywords

Apamin
Excitable membranes and synaptic transmission
N-Methyl-D-aspartate
Nifedipine
Postsynaptic mechanisms
Substantia nigra
Ventral tegmental area

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2004.06.022

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title = "Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro",

abstract = "Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms.",

keywords = "Apamin, Excitable membranes and synaptic transmission, N-Methyl-D-aspartate, Nifedipine, Postsynaptic mechanisms, Substantia nigra, Ventral tegmental area",

author = "Johnson, {Steven W.} and Wu, {Yan Na}",

note = "Funding Information: This work was supported by a grant from the National Institute of Mental Health (MH40416) and by the Portland VA Parkinson's Disease Research, Education, and Clinical Center (PADRECC).",

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doi = "10.1016/j.brainres.2004.06.022",

language = "English (US)",

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TY - JOUR

T1 - Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro

AU - Johnson, Steven W.

AU - Wu, Yan Na

N1 - Funding Information: This work was supported by a grant from the National Institute of Mental Health (MH40416) and by the Portland VA Parkinson's Disease Research, Education, and Clinical Center (PADRECC).

PY - 2004/9/3

Y1 - 2004/9/3

N2 - Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms.

AB - Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms.

KW - Apamin

KW - Excitable membranes and synaptic transmission

KW - N-Methyl-D-aspartate

KW - Nifedipine

KW - Postsynaptic mechanisms

KW - Substantia nigra

KW - Ventral tegmental area

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DO - 10.1016/j.brainres.2004.06.022

M3 - Article

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SN - 0006-8993

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EP - 296

JO - Brain research

JF - Brain research

IS - 1-2

ER -

Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro

Abstract

Keywords

ASJC Scopus subject areas

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