@article{6a6aadaccc4a4c15ab4082434d6f68bb,
title = "Myc requires distinct E2F activities to induce S phase and apoptosis",
abstract = "Previous work has shown that the Myc transcription factor induces transcription of the E2F1, E2F2, and E2F3 genes. Using primary mouse embryo fibroblasts deleted for individual E2F genes, we now show that Myc-induced S phase and apoptosis requires distinct E2F activities. The ability of Myc to induce S phase is impaired in the absence of either E2F2 or E2F3 but not E2F1 or E2F4. In contrast, the ability of Myc to induce apoptosis is markedly reduced in cells deleted for E2F1 but not E2F2 or E2F3. From this data, we propose that the induction of specific E2F activities is an essential component in the Myc pathways that control cell proliferation and cell fate decisions.",
author = "Gustavo Leone and Rosalie Sears and Erich Huang and Rachel Rempel and Faison Nuckolls and Park, {Chi Hyun} and Paloma Giangrande and Lizhao Wu and Saavedra, {Harold I.} and Field, {Seth J.} and Thompson, {Margaret A.} and Haidi Yang and Yuko Fujiwara and Greenberg, {Michael E.} and Stuart Orkin and Clay Smith and Nevins, {Joseph R.}",
note = "Funding Information: We thank Kaye Culler for help with the preparation of the manuscript. We are grateful to Richard Premont for providing the LoxP vectors. We thank Cheryl Bock for assistance in generating the E2F3 chimeric mice. G.L. is a V-Foundation Scholar, H.I.S. was supported by an NCI fellowship (CA85619), L.W. was supported by an NIH training grant (CA9338), R.S. was supported by an NIH grant (CA79983-02), R.R. and E.H. were supported by an NIH training grant (CA09111-25), and P.H.G. was supported by the Howard Hughes Medical Insititute. J.R.N. is an Investigator in the Howard Hughes Medical Institute. This work was supported by the Howard Hughes Medical Institute and by grants to G.L. (CA85619 and CA82259).",
year = "2001",
doi = "10.1016/S1097-2765(01)00275-1",
language = "English (US)",
volume = "8",
pages = "105--113",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "1",
}