TY - JOUR
T1 - Myocardial perfusion abnormalities in asymptomatic patients with systemic lupus erythematosus
AU - Hosenpud, Jeffrey D.
AU - Montanaro, Anthony
AU - Hart, Mark V.
AU - Haines, James E.
AU - Specht, H. David
AU - Bennett, Robert (Rob)
AU - Kloster, Frank E.
N1 - Funding Information:
From the Division of Cardiology and Rheumatology, Department of Medicine, and the Department of Nuclear Medicine, Oregon Health Sciences University, Portland, Oregon. This work was supported in part by U.S. Public Health Service Grants HD-10034 and HL-06409 (Research Fellowship), and the N. L. Tartar Research Fellowship Fund and the Heart Research Fund of Oregon Health Sciences University. Requests for reprints should be addressed to Dr. Jeffrey D. Hosenpud, Division of Cardiology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97201. Manuscript accepted February 9, 1984.
PY - 1984/8
Y1 - 1984/8
N2 - Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise thallium-201 cardiac scintigraphy. Segmental perfusion abnormalities were present in 10 of the 26 studies (38.5 percent). Five patients had reversible defects suggesting ischemia, four patients had persistent defects consistent with scar, and one patient had both reversible and persistent defects in two areas. There was no correlation between positive thallium results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive thallium-201 results (p < 0.05). It is concluded that segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined.
AB - Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise thallium-201 cardiac scintigraphy. Segmental perfusion abnormalities were present in 10 of the 26 studies (38.5 percent). Five patients had reversible defects suggesting ischemia, four patients had persistent defects consistent with scar, and one patient had both reversible and persistent defects in two areas. There was no correlation between positive thallium results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive thallium-201 results (p < 0.05). It is concluded that segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined.
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U2 - 10.1016/0002-9343(84)90704-6
DO - 10.1016/0002-9343(84)90704-6
M3 - Article
C2 - 6465176
AN - SCOPUS:0021215745
SN - 0002-9343
VL - 77
SP - 286
EP - 292
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 2
ER -