Myocardial T1 mapping with MRI: Comparison of look-locker and MOLLI sequences

Marcelo Souto Nacif, Evrim B. Turkbey, Neville Gai, Saman Nazarian, Rob J. Van Der Geest, Radwa A. Noureldin, Christopher T. Sibley, Martin Ugander, Songtao Liu, Andrew E. Arai, João A.C. Lima, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Purpose: To evaluate the relationship between "Look-Locker" (LL) and modified Look-Locker Inversion recovery (MOLLI) approaches for T1 mapping of the myocardium. Materials and Methods: A total of 168 myocardial T1 maps using MOLLI and 165 maps using LL were obtained in human subjects at 1.5 Tesla. The T1 values of the myocardium were calculated before and at five time points after gadolinium administration. All time and heart rate normalizations were done. The T1 values obtained were compared to determine the absolute and bias agreement. Results: The precontrast global T1 values were similar when measured by the LL and by MOLLI technique (mean, 1004.9 ms ± 120.3 versus 1034.1 ms ± 53.1, respectively, P = 0.26). Postcontrast myocardial T1 time from LL was significantly longer than MOLLI from 5 to 25 min (mean difference, LL - MOLLI was +61.8 ± 46.4 ms, P < 0.001). No significant differences in T1 values were noted between long and short axis measurements for either MOLLI or LL. Conclusion: Postcontrast LL and MOLLI showed very good agreement, although LL values are higher than MOLLI. Precontrast T1 values showed good agreement, however LL has greater limits of agreement. Short and long axis planes can reliably assess T1 values.

Original languageEnglish (US)
Pages (from-to)1367-1373
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number6
StatePublished - Dec 2011
Externally publishedYes


  • T1 mapping
  • diffuse myocardium fibrosis
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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