Myocardial tissue remodeling in adolescent obesity.

Ravi V. Shah, Siddique A. Abbasi, Tomas G. Neilan, Edward Hulten, Otavio Coelho-Filho, Alison Hoppin, Lynne Levitsky, Sarah de Ferranti, Erinn T. Rhodes, Avram Traum, Elizabeth Goodman, Henry Feng, Bobak Heydari, William S. Harris, Daniel M. Hoefner, Joseph P. McConnell, Ravi Seethamraju, Carsten Rickers, Raymond Y. Kwong, Michael Jerosch-Herold

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue-level markers within the myocardium that precede organ-level alterations have not been described. We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m(2)) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size-adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P<0.001) and with high-sensitivity C-reactive protein (r=0.47, P<0.05), serum triglycerides (r=0.51, P<0.05), and hemoglobin A1c (r=0.76, P<0.0001) in the obese stratum. Obese adolescents (particularly those with T2D) have subclinical alterations in myocardial tissue architecture associated with inflammation and insulin resistance. These alterations precede significant left ventricular hypertrophy or decreased cardiac function.

Original languageEnglish (US)
Pages (from-to)e000279
JournalJournal of the American Heart Association
Issue number4
StatePublished - Aug 2013
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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