Myosin-1c, the hair cell's adaptation motor

Peter G. Gillespie, Janet L. Cyr

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations


Given their prominent actin-rich subcellular specializations, it is no surprise that mechanosensitive hair cells of the inner ear exploit myosin molecules - the only known actin-dependent molecular motors - to carry out exotic but essential tasks. Recent experiments have confirmed that an unconventional myosin isozyme, myosin-1c, is a component of the hair cell's adaptation-motor complex. This complex carries out slow adaptation, provides tension to sensitize transduction channels, and may participate in assembly of the transduction apparatus. This review focuses on the detailed operation of the adaptation motor and the functional consequences of the incorporation of this specific myosin isozyme into the motor complex.

Original languageEnglish (US)
Pages (from-to)521-545
Number of pages25
JournalAnnual Review of Physiology
StatePublished - 2004


  • Adaptation
  • Microvilli
  • Myosin
  • Stereocilia
  • Transduction

ASJC Scopus subject areas

  • Physiology


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