Nafion-coated electrodes with high selectivity for CNS electrochemistry

Greg A. Gerhardt; Arvin F. Oke; Geza Nagy; Bita Moghaddam; Ralph N. Adams

doi:10.1016/0006-8993(84)90963-6

Nafion-coated electrodes with high selectivity for CNS electrochemistry

Greg A. Gerhardt, Arvin F. Oke, Geza Nagy, Bita Moghaddam, Ralph N. Adams

Research output: Contribution to journal › Article › peer-review

584 Scopus citations

Abstract

A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

Original language	English (US)
Pages (from-to)	390-395
Number of pages	6
Journal	Brain research
Volume	290
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90963-6
State	Published - Jan 9 1984
Externally published	Yes

Keywords

Nafion-coated electrodes
in vivo electrochemistry

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90963-6

Cite this

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title = "Nafion-coated electrodes with high selectivity for CNS electrochemistry",

abstract = "A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.",

keywords = "Nafion-coated electrodes, in vivo electrochemistry",

author = "Gerhardt, {Greg A.} and Oke, {Arvin F.} and Geza Nagy and Bita Moghaddam and Adams, {Ralph N.}",

note = "Funding Information: We wish to thank C. Martin for his generous gift of soluble Nation and for valuable discussions, We are much indebted to E. Murrill and T. Byerley of Midwest Research Institute for their help and the use of their autoclave equipment, and to M. Rice for important advice. Samples of Nation film were kindly supplied by E.I. du Pont de Nemours Company. This work was supported by NIH Grant NS08740.",

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doi = "10.1016/0006-8993(84)90963-6",

language = "English (US)",

volume = "290",

pages = "390--395",

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T1 - Nafion-coated electrodes with high selectivity for CNS electrochemistry

AU - Gerhardt, Greg A.

AU - Oke, Arvin F.

AU - Nagy, Geza

AU - Moghaddam, Bita

AU - Adams, Ralph N.

N1 - Funding Information: We wish to thank C. Martin for his generous gift of soluble Nation and for valuable discussions, We are much indebted to E. Murrill and T. Byerley of Midwest Research Institute for their help and the use of their autoclave equipment, and to M. Rice for important advice. Samples of Nation film were kindly supplied by E.I. du Pont de Nemours Company. This work was supported by NIH Grant NS08740.

PY - 1984/1/9

Y1 - 1984/1/9

N2 - A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

AB - A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

KW - Nafion-coated electrodes

KW - in vivo electrochemistry

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JO - Brain research

JF - Brain research

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ER -

Nafion-coated electrodes with high selectivity for CNS electrochemistry

Abstract

Keywords

ASJC Scopus subject areas

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