Nanoencapsulation of stem cells within polyelectrolyte multilayer shells

Nalinkanth G. Veerabadran; Poorna L. Goli; Skylar S. Stewart-Clark; Yuri M. Lvov; David K. Mills

doi:10.1002/mabi.200700061

Nanoencapsulation of stem cells within polyelectrolyte multilayer shells

Nalinkanth G. Veerabadran, Poorna L. Goli, Skylar S. Stewart-Clark, Yuri M. Lvov, David K. Mills

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications.

Original language	English (US)
Pages (from-to)	877-882
Number of pages	6
Journal	Macromolecular Bioscience
Volume	7
Issue number	7
DOIs	https://doi.org/10.1002/mabi.200700061
State	Published - Jul 9 2007
Externally published	Yes

Keywords

Encapsulation
Layer-by-layer
Mesenchymal stem cells
Nanolayers
Polyelectrolytes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1002/mabi.200700061

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title = "Nanoencapsulation of stem cells within polyelectrolyte multilayer shells",

abstract = "Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications.",

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doi = "10.1002/mabi.200700061",

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AU - Veerabadran, Nalinkanth G.

AU - Goli, Poorna L.

AU - Stewart-Clark, Skylar S.

AU - Lvov, Yuri M.

AU - Mills, David K.

PY - 2007/7/9

Y1 - 2007/7/9

N2 - Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications.

AB - Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications.

KW - Encapsulation

KW - Layer-by-layer

KW - Mesenchymal stem cells

KW - Nanolayers

KW - Polyelectrolytes

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Nanoencapsulation of stem cells within polyelectrolyte multilayer shells

Abstract

Keywords

ASJC Scopus subject areas

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