Nanometer measurements of motor protein and membrane glycoprotein movements

M. P. Sheetz; J. Gelles; E. R. Steuer; B. J. Schnapp; J. Dubinska; H. Qian; E. Elson

doi:10.1117/12.962707

Nanometer measurements of motor protein and membrane glycoprotein movements

M. P. Sheetz, J. Gelles, E. R. Steuer, B. J. Schnapp, J. Dubinska, H. Qian, E. Elson

Research output: Contribution to journal › Article › peer-review

Abstract

The recent application of digital imaging technologies to the analysis of video images from a DIC (differential interference contrast) light microscope has given 1-2 nm precision for the measurement of movements of submicron particles at 30 Hz. [Gelles et al., Nature 331(1988)450]. This technique has been applied to the study of the movements of 1) motor proteins (kinesin and cytoplasmic dynein) on microtubules (MTs) and 2) membrane glycoproteins in cellular plasma membranes. In both cases the nanometer measurements have provided important new insights into the molecular mechanisms which govern those biological movements.

Original language	English (US)
Pages (from-to)	264-265
Number of pages	2
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1161
DOIs	https://doi.org/10.1117/12.962707
State	Published - Dec 22 1989
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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abstract = "The recent application of digital imaging technologies to the analysis of video images from a DIC (differential interference contrast) light microscope has given 1-2 nm precision for the measurement of movements of submicron particles at 30 Hz. [Gelles et al., Nature 331(1988)450]. This technique has been applied to the study of the movements of 1) motor proteins (kinesin and cytoplasmic dynein) on microtubules (MTs) and 2) membrane glycoproteins in cellular plasma membranes. In both cases the nanometer measurements have provided important new insights into the molecular mechanisms which govern those biological movements.",

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AU - Sheetz, M. P.

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AU - Dubinska, J.

AU - Qian, H.

AU - Elson, E.

PY - 1989/12/22

Y1 - 1989/12/22

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AB - The recent application of digital imaging technologies to the analysis of video images from a DIC (differential interference contrast) light microscope has given 1-2 nm precision for the measurement of movements of submicron particles at 30 Hz. [Gelles et al., Nature 331(1988)450]. This technique has been applied to the study of the movements of 1) motor proteins (kinesin and cytoplasmic dynein) on microtubules (MTs) and 2) membrane glycoproteins in cellular plasma membranes. In both cases the nanometer measurements have provided important new insights into the molecular mechanisms which govern those biological movements.

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Nanometer measurements of motor protein and membrane glycoprotein movements

Abstract

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