Natural history of growth hormone receptor deficiency

A. L. Rosenbloom, V. Martinez, J. H. Kranzier, L. K. Bachrach, R. G. Rosenfeld, J. Guevara-Aguirre

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This review discusses the natural history of growth hormone receptor deficiency (GHRD) in relation to epidemiology, mortality, growth, certain aspects of body composition, and intellectual development. The majority of affected individuals are of Semitic origin and 90% come from the Indian peninsula, the Middle East, or elsewhere in the Mediterranean. There is a twofold increased mortality before the age of 7 years for children with GHRD. Affected adults may have increased cardiovascular risk resulting from increased total cholesterol and low-density lipoprotein cholesterol, unrelated to adiposity or insulin resistance. Intrauterine growth is affected minimally, if at all. Within a genetically homogeneous population in Ecuador, postnatal growth effects are as variable as in a large genetically heterogeneous population. There is no influence of parental heights. Areal bone mineral density is reduced in adults with GHRD, but estimated volumetric bone density (bone mineral apparent density) is normal. Intellectual development is unaffected by GHRD.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics, Supplement
Issue number428
StatePublished - Jan 1 1999


  • Body composition
  • Growth
  • Growth hormone receptor deficiency
  • Insulin-like growth factor I deficiency
  • Intellectual development
  • Laron syndrome
  • Natural history

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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