Neural control of fasting-induced torpor in mice

Timna Hitrec, Marco Luppi, Stefano Bastianini, Fabio Squarcio, Chiara Berteotti, Viviana Lo Martire, Davide Martelli, Alessandra Occhinegro, Domenico Tupone, Giovanna Zoccoli, Roberto Amici, Matteo Cerri

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed by a drop in body temperature. To enter torpor, the activation of all thermogenic organs that could potentially defend body temperature must be prevented. Most of these organs, such as the brown adipose tissue, are controlled by the key thermoregulatory region of the Raphe Pallidus (RPa). Currently, it is not known which brain areas mediate the entrance into torpor. To identify these areas, the expression of the early gene c-Fos at torpor onset was assessed in different brain regions in mice injected with a retrograde tracer (Cholera Toxin subunit b, CTb) into the RPa region. The results show a network of hypothalamic neurons that are specifically activated at torpor onset and a direct torpor-specific projection from the Dorsomedial Hypothalamus to the RPa that could putatively mediate the suppression of thermogenesis during torpor.

Original languageEnglish (US)
Article number15462
JournalScientific Reports
Issue number1
StatePublished - Dec 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Neural control of fasting-induced torpor in mice'. Together they form a unique fingerprint.

Cite this