Neurologic complications of myeloma

Chafic Y. Karam, Michelle L. Mauermann

Research output: Chapter in Book/Report/Conference proceedingChapter


Patients with multiple myeloma (MM) frequently develop neurological complications related to the disease or its treatment [ 1 – 3 ]. These neurological complications may affect the central nervous system (CNS) [ 4 ] or more commonly the peripheral nervous system (PNS) [ 1, 5 ]. Neurological complications can result from: (a) Direct infi ltration of the nervous system by neoplastic cells [ 4 ] (b) Indirect effect such as paraneoplastic syndrome or amyloid deposition [ 5 ] (c) Iatrogenic effect during multiple myeloma treatment [ 1 ] (d) Toxic-metabolic syndrome related to systemic complications of multiple myeloma [ 6 ] (e) A combination of the above Furthermore, a neurological syndrome can be the presenting sign of multiple myeloma [ 7 ]. In this chapter we will discuss these different neurological complications of myeloma by system (CNS vs. PNS) and the management of these complications (Table 20.1).

Original languageEnglish (US)
Title of host publicationMultiple Myeloma
Subtitle of host publicationDiagnosis and Treatment
PublisherSpringer New York
Number of pages12
ISBN (Electronic)9781461485209
ISBN (Print)9781461485193
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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