Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Rosemarie Drake-Baumann; Fredrick J. Seil; Peter S. Spencer

doi:10.1016/S0928-4257(98)80038-7

Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Rosemarie Drake-Baumann, Fredrick J. Seil, Peter S. Spencer

Neurology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.

Original language	English (US)
Pages (from-to)	305-308
Number of pages	4
Journal	Journal of Physiology Paris
Volume	92
Issue number	3-4
DOIs	https://doi.org/10.1016/S0928-4257(98)80038-7
State	Published - 1998

ASJC Scopus subject areas

Neuroscience(all)
Physiology (medical)

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title = "Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture",

abstract = "Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.",

author = "Rosemarie Drake-Baumann and Seil, {Fredrick J.} and Spencer, {Peter S.}",

note = "Funding Information: Supported by a grant from the U.S. Department of Veterans",

year = "1998",

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AU - Drake-Baumann, Rosemarie

AU - Seil, Fredrick J.

AU - Spencer, Peter S.

N1 - Funding Information: Supported by a grant from the U.S. Department of Veterans

PY - 1998

Y1 - 1998

N2 - Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.

AB - Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.

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Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Abstract

ASJC Scopus subject areas

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