TY - JOUR
T1 - Neuronal migration during development and the amyloid precursor protein
AU - Copenhaver, Philip F.
AU - Ramaker, Jenna M.
N1 - Funding Information:
Authors’ research reported in this publication was supported by grants from the National Institute for Neurological Disease and Stroke of the National Institutes of Health ( RO1 AG025525 and R21 NS078363 ) to PFC , who also received support from an OHSU Presidential Bridge Funding Award. JMR received support from a grant from the Oregon Partners for Alzheimer's Research and from training grant support from the National Institute on Aging , National Institutes of Health (T32 AG023477). We thank Drs. Doris Kretzschmar for critical input on the manuscript. We are grateful to Dr. Stefanie Kaech and Ms. Aurelie Snyder for their assistance with confocal microscopy and image analysis that was performed in the Advanced Light Microscopy Core, Jungers Center at OHSU, which is supported in part by National Institutes of Health grant # P30 NS061800.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The Amyloid Precursor Protein (APP) is the source of amyloid peptides that accumulate in Alzheimer's disease. However, members of the APP family are strongly expressed in the developing nervous systems of invertebrates and vertebrates, where they regulate neuronal guidance, synaptic remodeling, and injury responses. In contrast to mammals, insects express only one APP ortholog (APPL), simplifying investigations into its normal functions. Recent studies have shown that APPL regulates neuronal migration in the developing insect nervous system, analogous to the roles ascribed to APP family proteins in the mammalian cortex. The comparative simplicity of insect systems offers new opportunities for deciphering the signaling mechanisms by which this enigmatic class of proteins contributes to the formation and function of the nervous system.
AB - The Amyloid Precursor Protein (APP) is the source of amyloid peptides that accumulate in Alzheimer's disease. However, members of the APP family are strongly expressed in the developing nervous systems of invertebrates and vertebrates, where they regulate neuronal guidance, synaptic remodeling, and injury responses. In contrast to mammals, insects express only one APP ortholog (APPL), simplifying investigations into its normal functions. Recent studies have shown that APPL regulates neuronal migration in the developing insect nervous system, analogous to the roles ascribed to APP family proteins in the mammalian cortex. The comparative simplicity of insect systems offers new opportunities for deciphering the signaling mechanisms by which this enigmatic class of proteins contributes to the formation and function of the nervous system.
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U2 - 10.1016/j.cois.2016.08.001
DO - 10.1016/j.cois.2016.08.001
M3 - Review article
C2 - 27939704
AN - SCOPUS:84983650362
SN - 2214-5745
VL - 18
SP - 1
EP - 10
JO - Current Opinion in Insect Science
JF - Current Opinion in Insect Science
ER -