Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats

Vemuganti L. Raghavendra Rao; Aclan Dogan; Kathryn G. Todd; Kellie K. Bowen; Robert J. Dempsey

doi:10.1016/S0006-8993(01)02617-8

Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats

Vemuganti L. Raghavendra Rao, Aclan Dogan, Kathryn G. Todd, Kellie K. Bowen, Robert J. Dempsey

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.

Original language	English (US)
Pages (from-to)	96-100
Number of pages	5
Journal	Brain research
Volume	911
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(01)02617-8
State	Published - Aug 17 2001
Externally published	Yes

Keywords

Excitotoxicity
Glutamate antagonist
Memantine
Neuroprotection
Secondary neuronal death
Traumatic brain injury

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(01)02617-8

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abstract = "This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.",

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AU - Raghavendra Rao, Vemuganti L.

AU - Dogan, Aclan

AU - Todd, Kathryn G.

AU - Bowen, Kellie K.

AU - Dempsey, Robert J.

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KW - Glutamate antagonist

KW - Memantine

KW - Neuroprotection

KW - Secondary neuronal death

KW - Traumatic brain injury

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Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats

Abstract

Keywords

ASJC Scopus subject areas

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