@article{177370b1e17d4f9e951afe9767675af2,
title = "Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination",
abstract = "Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure. Neutralization activity against the 5 SARS-CoV-2 spike sequences was measured by a SARS-CoV-2-pseudotyped spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared with WT spike protein, these nAbs were less effective against the Delta and Mu spike variants. Vaccination during the third trimester induced higher cord-nAb levels at delivery than did infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared with infection during the first trimester. The transfer ratio (cord nAb level divided by maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicits effective nAbs with differing neutralization kinetics that are influenced by gestational time of exposure.",
author = "Yusuke Matsui and Lin Li and Mary Prahl and Cassidy, {Arianna G.} and Nida Ozarslan and Yarden Golan and Gonzalez, {Veronica J.} and Lin, {Christine Y.} and Unurzul Jigmeddagva and Chidboy, {Megan A.} and Mauricio Montano and Taha, {Taha Y.} and Khalid, {Mir M.} and Bharath Sreekumar and Hayashi, {Jennifer M.} and Chen, {Pei Yi} and Kumar, {G. Renuka} and Lakshmi Warrier and Wu, {Alan H.B.} and Dongli Song and Priya Jegatheesan and Rai, {Daljeet S.} and Balaji Govindaswami and Jordan Needens and Monica Rincon and Leslie Myatt and Asiodu, {Ifeyinwa V.} and Flaherman, {Valerie J.} and Yalda Afshar and Jacoby, {Vanessa L.} and Murtha, {Amy P.} and Robinson, {Joshua F.} and Melanie Ott and Greene, {Warner C.} and Gaw, {Stephanie L.}",
note = "Funding Information: We thank the mothers and infants who participated in this study. These studies were supported by the Bill and Melinda Gates Foundation (INV-017035 to SLG and VJF); the Marino Family Foundation (to MP); the NIH (National Institute of Allergy and Infectious Diseases grants K23AI127886 [to MP] and K08AI141728 [to SLG]); the Krzyzewski Family (to APM and SLG); UCSF National Center of Excellence in Women{\textquoteright}s Health (to SLG, VJF, YA, and VLJ); the Roddenberry Foundation (YM and WCG); Centers for Disease Control and Prevention Foundation (to SLG, VJF, YA, and VLJ); the Valley Medical Center Foundation (to DS, PJ, and DSR), and individual donors who provided support through our crowdfunding websites: https://givingtogether.ucsf.edu/fundraiser/2718761 and https://spark.ucla.edu/project/20775. Publisher Copyright: {\textcopyright} 2022, Matsui et al.",
year = "2022",
month = jun,
day = "22",
doi = "10.1172/jci.insight.157354",
language = "English (US)",
volume = "7",
journal = "JCI Insight",
issn = "2379-3708",
publisher = "The American Society for Clinical Investigation",
number = "12",
}