Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination

Yusuke Matsui; Lin Li; Mary Prahl; Arianna G. Cassidy; Nida Ozarslan; Yarden Golan; Veronica J. Gonzalez; Christine Y. Lin; Unurzul Jigmeddagva; Megan A. Chidboy; Mauricio Montano; Taha Y. Taha; Mir M. Khalid; Bharath Sreekumar; Jennifer M. Hayashi; Pei Yi Chen; G. Renuka Kumar; Lakshmi Warrier; Alan H.B. Wu; Dongli Song; Priya Jegatheesan; Daljeet S. Rai; Balaji Govindaswami; Jordan Needens; Monica Rincon; Leslie Myatt; Ifeyinwa V. Asiodu; Valerie J. Flaherman; Yalda Afshar; Vanessa L. Jacoby; Amy P. Murtha; Joshua F. Robinson; Melanie Ott; Warner C. Greene; Stephanie L. Gaw

doi:10.1172/jci.insight.157354

Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination

Yusuke Matsui, Lin Li, Mary Prahl, Arianna G. Cassidy, Nida Ozarslan, Yarden Golan, Veronica J. Gonzalez, Christine Y. Lin, Unurzul Jigmeddagva, Megan A. Chidboy, Mauricio Montano, Taha Y. Taha, Mir M. Khalid, Bharath Sreekumar, Jennifer M. Hayashi, Pei Yi Chen, G. Renuka Kumar, Lakshmi Warrier, Alan H.B. Wu, Dongli SongPriya Jegatheesan, Daljeet S. Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Ifeyinwa V. Asiodu, Valerie J. Flaherman, Yalda Afshar, Vanessa L. Jacoby, Amy P. Murtha, Joshua F. Robinson, Melanie Ott, Warner C. Greene, Stephanie L. Gaw

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure. Neutralization activity against the 5 SARS-CoV-2 spike sequences was measured by a SARS-CoV-2-pseudotyped spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared with WT spike protein, these nAbs were less effective against the Delta and Mu spike variants. Vaccination during the third trimester induced higher cord-nAb levels at delivery than did infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared with infection during the first trimester. The transfer ratio (cord nAb level divided by maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicits effective nAbs with differing neutralization kinetics that are influenced by gestational time of exposure.

Original language	English (US)
Article number	e157354
Journal	JCI Insight
Volume	7
Issue number	12
DOIs	https://doi.org/10.1172/jci.insight.157354
State	Published - Jun 22 2022

ASJC Scopus subject areas

General Medicine

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10.1172/jci.insight.157354

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Matsui, Y., Li, L., Prahl, M., Cassidy, A. G., Ozarslan, N., Golan, Y., Gonzalez, V. J., Lin, C. Y., Jigmeddagva, U., Chidboy, M. A., Montano, M., Taha, T. Y., Khalid, M. M., Sreekumar, B., Hayashi, J. M., Chen, P. Y., Kumar, G. R., Warrier, L., Wu, A. H. B., ... Gaw, S. L. (2022). Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination. JCI Insight, 7(12), Article e157354. https://doi.org/10.1172/jci.insight.157354

Matsui, Y, Li, L, Prahl, M, Cassidy, AG, Ozarslan, N, Golan, Y, Gonzalez, VJ, Lin, CY, Jigmeddagva, U, Chidboy, MA, Montano, M, Taha, TY, Khalid, MM, Sreekumar, B, Hayashi, JM, Chen, PY, Kumar, GR, Warrier, L, Wu, AHB, Song, D, Jegatheesan, P, Rai, DS, Govindaswami, B, Needens, J, Rincon, M, Myatt, L, Asiodu, IV, Flaherman, VJ, Afshar, Y, Jacoby, VL, Murtha, AP, Robinson, JF, Ott, M, Greene, WC & Gaw, SL 2022, 'Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination', JCI Insight, vol. 7, no. 12, e157354. https://doi.org/10.1172/jci.insight.157354

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title = "Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination",

abstract = "Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure. Neutralization activity against the 5 SARS-CoV-2 spike sequences was measured by a SARS-CoV-2-pseudotyped spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared with WT spike protein, these nAbs were less effective against the Delta and Mu spike variants. Vaccination during the third trimester induced higher cord-nAb levels at delivery than did infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared with infection during the first trimester. The transfer ratio (cord nAb level divided by maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicits effective nAbs with differing neutralization kinetics that are influenced by gestational time of exposure.",

author = "Yusuke Matsui and Lin Li and Mary Prahl and Cassidy, {Arianna G.} and Nida Ozarslan and Yarden Golan and Gonzalez, {Veronica J.} and Lin, {Christine Y.} and Unurzul Jigmeddagva and Chidboy, {Megan A.} and Mauricio Montano and Taha, {Taha Y.} and Khalid, {Mir M.} and Bharath Sreekumar and Hayashi, {Jennifer M.} and Chen, {Pei Yi} and Kumar, {G. Renuka} and Lakshmi Warrier and Wu, {Alan H.B.} and Dongli Song and Priya Jegatheesan and Rai, {Daljeet S.} and Balaji Govindaswami and Jordan Needens and Monica Rincon and Leslie Myatt and Asiodu, {Ifeyinwa V.} and Flaherman, {Valerie J.} and Yalda Afshar and Jacoby, {Vanessa L.} and Murtha, {Amy P.} and Robinson, {Joshua F.} and Melanie Ott and Greene, {Warner C.} and Gaw, {Stephanie L.}",

note = "Publisher Copyright: {\textcopyright} 2022, Matsui et al.",

year = "2022",

month = jun,

day = "22",

doi = "10.1172/jci.insight.157354",

language = "English (US)",

volume = "7",

journal = "JCI Insight",

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T1 - Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination

AU - Matsui, Yusuke

AU - Li, Lin

AU - Prahl, Mary

AU - Cassidy, Arianna G.

AU - Ozarslan, Nida

AU - Golan, Yarden

AU - Gonzalez, Veronica J.

AU - Lin, Christine Y.

AU - Jigmeddagva, Unurzul

AU - Chidboy, Megan A.

AU - Montano, Mauricio

AU - Taha, Taha Y.

AU - Khalid, Mir M.

AU - Sreekumar, Bharath

AU - Hayashi, Jennifer M.

AU - Chen, Pei Yi

AU - Kumar, G. Renuka

AU - Warrier, Lakshmi

AU - Wu, Alan H.B.

AU - Song, Dongli

AU - Jegatheesan, Priya

AU - Rai, Daljeet S.

AU - Govindaswami, Balaji

AU - Needens, Jordan

AU - Rincon, Monica

AU - Myatt, Leslie

AU - Asiodu, Ifeyinwa V.

AU - Flaherman, Valerie J.

AU - Afshar, Yalda

AU - Jacoby, Vanessa L.

AU - Murtha, Amy P.

AU - Robinson, Joshua F.

AU - Ott, Melanie

AU - Greene, Warner C.

AU - Gaw, Stephanie L.

PY - 2022/6/22

Y1 - 2022/6/22

N2 - Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure. Neutralization activity against the 5 SARS-CoV-2 spike sequences was measured by a SARS-CoV-2-pseudotyped spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared with WT spike protein, these nAbs were less effective against the Delta and Mu spike variants. Vaccination during the third trimester induced higher cord-nAb levels at delivery than did infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared with infection during the first trimester. The transfer ratio (cord nAb level divided by maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicits effective nAbs with differing neutralization kinetics that are influenced by gestational time of exposure.

AB - Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure. Neutralization activity against the 5 SARS-CoV-2 spike sequences was measured by a SARS-CoV-2-pseudotyped spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared with WT spike protein, these nAbs were less effective against the Delta and Mu spike variants. Vaccination during the third trimester induced higher cord-nAb levels at delivery than did infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared with infection during the first trimester. The transfer ratio (cord nAb level divided by maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicits effective nAbs with differing neutralization kinetics that are influenced by gestational time of exposure.

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ER -

Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination

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