TY - JOUR
T1 - New and emerging therapeutic options for malignant pleural mesothelioma
T2 - Review of early clinical trials
AU - Kotova, Svetlana
AU - Wong, Raymond M.
AU - Cameron, Robert B.
N1 - Publisher Copyright:
© 2015 Kotova et al.
PY - 2015/1/23
Y1 - 2015/1/23
N2 - Malignant pleural mesothelioma (MPM) is a rare tumor that is challenging to control. Despite some benefit from using the multimodality-approach (surgery, combination chemotherapy and radiation), survival remains poor. However, current research produced a list of potential therapies. Here, we summarize significant new preclinical and early clinical developments in treatment of MPM, which include mesothelin specific antibody and toxin therapies, interleukin-4 (IL-4) receptor toxins, dendritic cell vaccines, immune checkpoint inhibitors, and gene-based therapies. In addition, several local modalities such as photodynamic therapy, postoperative lavage using betadine, and cryotherapy for local recurrence, have also shown to be effective for local control of disease.
AB - Malignant pleural mesothelioma (MPM) is a rare tumor that is challenging to control. Despite some benefit from using the multimodality-approach (surgery, combination chemotherapy and radiation), survival remains poor. However, current research produced a list of potential therapies. Here, we summarize significant new preclinical and early clinical developments in treatment of MPM, which include mesothelin specific antibody and toxin therapies, interleukin-4 (IL-4) receptor toxins, dendritic cell vaccines, immune checkpoint inhibitors, and gene-based therapies. In addition, several local modalities such as photodynamic therapy, postoperative lavage using betadine, and cryotherapy for local recurrence, have also shown to be effective for local control of disease.
KW - Local therapies
KW - MPM
KW - New targeted
KW - Systemic
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M3 - Article
AN - SCOPUS:84982295071
SN - 1179-1322
VL - 7
SP - 51
EP - 63
JO - Cancer Management and Research
JF - Cancer Management and Research
ER -