New-onset atrial fibrillation after aortic valve replacement: Comparison of transfemoral, transapical, transaortic, and surgical approaches

Tanyanan Tanawuttiwat, Brian P. O'Neill, Mauricio G. Cohen, Orawee Chinthakanan, Alan W. Heldman, Claudia A. Martinez, Carlos E. Alfonso, Raul D. Mitrani, Conrad J. Macon, Roger G. Carrillo, Donald B. Williams, William W. O'Neill, Robert J. Myerburg

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Objectives: This study sought to determine the incidence of new-onset atrial fibrillation (AF) associated with different methods of isolated aortic valve replacement (AVR) - transfemoral (TF), transapical (TA), and transaortic (TAo) catheter-based valve replacement and conventional surgical approaches. Background: The relative incidences of AF associated with the various access routes for AVR have not been well characterized. Methods: In this single-center, retrospective cohort study, we evaluated a total of 231 consecutive patients who underwent AVR for degenerative aortic stenosis (AS) between March 2010 and September 2012. Patients with a history of paroxysmal, persistent, or chronic AF, with bicuspid aortic valves, and patients who died within 48 h after AVR were excluded. A total of 123 patients (53% of total group) qualified for inclusion. Data on documented episodes of new-onset AF, along with all clinical, echocardiographic, procedural, and 30-day follow-up data, were collated. Results: AF occurred in 52 patients (42.3%). AF incidence varied according to the procedural method. AF occurred in 60% of patients who underwent surgical AVR (SAVR), in 53% after TA-TAVR, in 33% after TAo-TAVR cases, and 14% after TF-TAVR. The episodes occurred at a median time interval of 53 (25th to 75th percentile, 41 to 87) h after completion of the procedure. Procedures without pericardiotomy had an 82% risk reduction of AF compared with those with pericardiotomy (adjusted odds ratio: 0.18; 95% confidence interval: 0.05 to 0.59). Conclusions: AF was a common complication of AVR with a cumulative incidence of >40% in elderly patients with degenerative AS who underwent either SAVR or TAVR. AF was most common with SAVR and least common with TF-TAVR. Procedures without pericardiotomy were associated with a lower incidence of AF.

Original languageEnglish (US)
Pages (from-to)1510-1519
Number of pages10
JournalJournal of the American College of Cardiology
Issue number15
StatePublished - Apr 22 2014
Externally publishedYes


  • atrial fibrillation
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'New-onset atrial fibrillation after aortic valve replacement: Comparison of transfemoral, transapical, transaortic, and surgical approaches'. Together they form a unique fingerprint.

Cite this