New Vistas in the Biology of the Flagellum—Leishmania Parasites

Scott M. Landfear

doi:10.3390/pathogens11040447

New Vistas in the Biology of the Flagellum—Leishmania Parasites

Scott M. Landfear

Molecular Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Like other kinetoplastid protozoa, the flagellum in Leishmania parasites plays central roles throughout the life cycle. Discoveries over the past decade have begun to elucidate flagellar functions at the molecular level in both the insect vector stage promastigotes and intra-macrophage amastigotes. This focused review will highlight recent advances that contribute to understanding flagellar function in the various biological contexts encountered by Leishmania parasites.

Original language	English (US)
Article number	447
Journal	Pathogens
Volume	11
Issue number	4
DOIs	https://doi.org/10.3390/pathogens11040447
State	Published - Apr 2022

Keywords

flagellar membrane proteins
flagellum
flagellum attachment zone
protein composition and function
protein targeting to flagellum

ASJC Scopus subject areas

Immunology and Allergy
Molecular Biology
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

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10.3390/pathogens11040447

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abstract = "Like other kinetoplastid protozoa, the flagellum in Leishmania parasites plays central roles throughout the life cycle. Discoveries over the past decade have begun to elucidate flagellar functions at the molecular level in both the insect vector stage promastigotes and intra-macrophage amastigotes. This focused review will highlight recent advances that contribute to understanding flagellar function in the various biological contexts encountered by Leishmania parasites.",

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AB - Like other kinetoplastid protozoa, the flagellum in Leishmania parasites plays central roles throughout the life cycle. Discoveries over the past decade have begun to elucidate flagellar functions at the molecular level in both the insect vector stage promastigotes and intra-macrophage amastigotes. This focused review will highlight recent advances that contribute to understanding flagellar function in the various biological contexts encountered by Leishmania parasites.

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KW - flagellum attachment zone

KW - protein composition and function

KW - protein targeting to flagellum

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New Vistas in the Biology of the Flagellum—Leishmania Parasites

Abstract

Keywords

ASJC Scopus subject areas

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