NMDA receptors turn to another channel for inhibition

N. E. Schoppa; G. L. Westbrook

doi:10.1016/S0896-6273(01)00442-1

NMDA receptors turn to another channel for inhibition

N. E. Schoppa, G. L. Westbrook

Vollum Institute

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Activation of glutamate receptors generally increases neuronal excitability. However, Isaacson and Murphy show in olfactory bulb granule cells that NMDA receptor-mediated calcium influx couples to large conductance (BK) calcium-activated potassium channels. The resulting inhibition is long lasting, which may be critical to the operation of the dynamic circuitry of the bulb.

Original language	English (US)
Pages (from-to)	877-879
Number of pages	3
Journal	Neuron
Volume	31
Issue number	6
DOIs	https://doi.org/10.1016/S0896-6273(01)00442-1
State	Published - Sep 27 2001

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0896-6273(01)00442-1

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title = "NMDA receptors turn to another channel for inhibition",

abstract = "Activation of glutamate receptors generally increases neuronal excitability. However, Isaacson and Murphy show in olfactory bulb granule cells that NMDA receptor-mediated calcium influx couples to large conductance (BK) calcium-activated potassium channels. The resulting inhibition is long lasting, which may be critical to the operation of the dynamic circuitry of the bulb.",

author = "Schoppa, {N. E.} and Westbrook, {G. L.}",

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AU - Schoppa, N. E.

AU - Westbrook, G. L.

PY - 2001/9/27

Y1 - 2001/9/27

N2 - Activation of glutamate receptors generally increases neuronal excitability. However, Isaacson and Murphy show in olfactory bulb granule cells that NMDA receptor-mediated calcium influx couples to large conductance (BK) calcium-activated potassium channels. The resulting inhibition is long lasting, which may be critical to the operation of the dynamic circuitry of the bulb.

AB - Activation of glutamate receptors generally increases neuronal excitability. However, Isaacson and Murphy show in olfactory bulb granule cells that NMDA receptor-mediated calcium influx couples to large conductance (BK) calcium-activated potassium channels. The resulting inhibition is long lasting, which may be critical to the operation of the dynamic circuitry of the bulb.

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U2 - 10.1016/S0896-6273(01)00442-1

DO - 10.1016/S0896-6273(01)00442-1

M3 - Review article

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AN - SCOPUS:0035959977

SN - 0896-6273

VL - 31

SP - 877

EP - 879

JO - Neuron

JF - Neuron

IS - 6

ER -

NMDA receptors turn to another channel for inhibition

Abstract

ASJC Scopus subject areas

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