TY - JOUR
T1 - NompC TRP channel required for vertebrate sensory hair cell mechanotransduction
AU - Sidi, Samuel
AU - Friedrich, Rainer W.
AU - Nicolson, Teresa
PY - 2003/7/4
Y1 - 2003/7/4
N2 - The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and etectrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.
AB - The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and etectrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.
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U2 - 10.1126/science.1084370
DO - 10.1126/science.1084370
M3 - Article
C2 - 12805553
AN - SCOPUS:0037710542
SN - 0036-8075
VL - 301
SP - 96
EP - 99
JO - Science
JF - Science
IS - 5629
ER -