Non-invasive assessment of the pyramidal tract and motor pathway of primates

A. C. Ludolph, J. Hugon, P. S. Spencer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Non-invasive direct stimulation of the motor cortex of cynomolgus monkeys has been used to assess in awake and anesthetized animals the central and peripheral conduction times of the motor pathway and to measure the latencies of the descending spinal volley of the pyramidal tracts. Repetitive stimulation failed to induce convulsive activity or detectable pathological changes. Peripheral latencies were comparable with those obtained from F-wave analysis. Central conduction times for corticospinal tracts regulating the upper and lower limbs were 2.7 msec and 5.4 msec, respectively, the estimated conduction velocity (67.5 m/sec) corresponding to results obtained by invasive methods. These studies provide a new and apparently safe technique to assess non-invasively the functional status of the central motor pathway in primates, a method that might also find utility in clinical practice.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology
Issue number1
StatePublished - Jul 1987
Externally publishedYes


  • Motor cortex stimulation
  • Primate
  • Pyramidal tract

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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