Normal growth and essential fatty acid status in children with intestinal failure on lipid limitation

Gillian Lam, Irina G. Strogach, Nicole Baron, John F. Thompson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives: Lipid limitation, that is, ≤1 g-kg-1-day-1 of soy oil lipid emulsion (SOLE), has been suggested as a method to reduce the risk of intestinal failure (IF)-associated liver disease (IFALD). There are limited data as to the effects of this strategy on growth and essential fatty acid (EFA) status. The aim of the study was to assess growth, prevalence of cholestasis, and EFA deficiency in patients with IF who were provided daily SOLE at a dose ≤1 g-kg-1-day-1. Methods: Medical records were retrospectively reviewed from 9 patients age 16 months to 8 years who had IF requiring parenteral nutrition support for >12 months. Parenteral nutrition supplied a mean of 53% of total energy (range 24%-86%). Results: Mean SOLE dose was 0.61 g-kg-1-day-1 (range 0.4-0.81 g-kg-1-day-1). After 1 month of lipid limitation between 2011 and 2014, no patient developed IFALD as defined by a direct bilirubin >2 mg/dL. The median direct bilirubin was 0.1 mg/dL (range 0.075-0.85 mg/dL). No patient developed EFA deficiency as defined by a triene-to-tetraene ratio >0.2 (median 0.026, range 0.017-0.076). Height z scores increased from mean of-2.568 (range-10.8 to 0.878) to-0.484 (range-3.546 to 0.822). Weight z scores increased from mean of-1.412 (range-5.871 to 0.906) to-0.595 (range-2.178 to 0.926). Conclusions: In this case series, lipid limitation allowed normal growth while preventing the development of cholestasis and EFA deficiency.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Issue number2
StatePublished - Feb 1 2016


  • Intestinal failure
  • intestinal failure-associated liver disease
  • intravenous lipids
  • lipid emulsion
  • lipid limitation
  • parenteral nutrition- associated liver disease
  • short bowel syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology


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